Ah, laudanum...how many of those highly respectable Victorian ladies with vague illnesses passed their hours lying on the chaise lounge, essentially stoned? They would have expressed proper horror at an opium den, but were junkies themselves. Poor Elizabeth Siddal took an overdose of laudanum - the big question being whether it was accident or suicide.
Then there are those unforgettable scenes relating to cocaine use in Conan Doyle's Sherlock Holmes stories - the conclusion to 'The Sign of Four':
"The division seems rather unfair," I remarked. "You have done all the work in this business. I get a wife out of it, Jones gets the credit, pray what remains for you?"
"For me," said Sherlock Holmes, "there still remains the cocaine-bottle." And he stretched his long white hand up for it.